Stimulatory Agents and Skin Substitute

Skin substitutes are tissue-engineered products that are intended to temporarily or permanently replace the skin's form and function. In chronic, non-healing ulcers such as pressure ulcers, diabetic neuropathic ulcers, and vascular insufficiency ulcers, skin substitutes are frequently used. These wounds result in significant morbidity, including an increased risk of infection, amputation of limbs, and death. Skin substitutes have the potential to improve healing rates and minimize complications in a variety of other skin wounds, including those caused by burns, ischemia, pressure, trauma, surgery, and skin disorders. Additionally, skin substitutes are used in patients who have a compromised ability to heal and in situations where skin coverage is insufficient. The objectives of treating acute and chronic wounds with skin substitutes are to provide temporary coverage or permanent wound closure, to decrease healing time, to decrease postoperative contracture, to improve function, and to minimize morbidity associated with more invasive treatments such as skin grafting.